HIGHLIGHTS
- who: Paula Fernu00e1ndez-Palanca from the (UNIVERSITY) have published the paper: Hepatocellular carcinoma cells loss lenvatinib efficacy in vitro through autophagy and hypoxia response-derived neuropilin-1 degradation, in the Journal: (JOURNAL)
- what: The authors evaluated the role of NRP1 on the loss of therapeutic effectiveness of lenvatinib and the modulation exerted by the HIF-1u03b1-mediated response to hypoxia. These findings and those observed in the study provide interesting results and support the crucial role of the hypoxic microenvironment on the cellular response to lenvatinib that could drive to chemotherapeutic resistance. The authors aimed . . .
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