Spatial genomics maps the structure, nature and evolution of cancer clones

HIGHLIGHTS

  • who: Artem Lomakin from the (UNIVERSITY) have published the Article: Spatial genomics maps the structure, nature and evolution of cancer clones, in the Journal: (JOURNAL) of 21/04/2021
  • how: To address this need the authors developed a workflow that generates detailed quantitative maps of genetic subclone composition across whole-tumour sections.

SUMMARY

    BaSISS and transcript detection are performed as previously described for gene_expression ISS using cyclical microscopy27,30 (Fig 1a and Supplementary Methods). Transcriptional programs were also distinct, with statistically significant differences in gene_expression for 12 of 91 genes between . . .

     

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