Usp22 regulates lipidome accumulation by stabilizing pparγ in hepatocellular carcinoma

HIGHLIGHTS

• who: Zhen Ning from the Dalian Institute Medical University Targeted Drugs in Hepatobiliary and Pancreatic Cancer, Dalian, China have published the research: USP22 regulates lipidome accumulation by stabilizing PPARu03b3 in hepatocellular carcinoma, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors demonstrate that USP22 stabilizes PPARu03b3 through K48-linked deubiquitination, and significantly deubiquitinates the E3 ligases pVHL and CRL4BAhR ubiquitination sites (K404/434 and K240/ 265, respectively).
• how: Previously the authors conducted a study in the field of deubiquitination and successfully mapped the key deubiquitination molecular interaction networks in different cancers17. Previously . . .
  

   

  

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