Nuclear vav3 is required for polycomb repression complex-1 activity in b-cell lymphoblastic leukemogenesis

HIGHLIGHTS

• who: R. C. Nayak from the Hoxworth Blood Center, University of have published the research work: Nuclear Vav3 is required for polycomb repression complex-1 activity in B-cell lymphoblastic leukemogenesis, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors demonstrate that the mechanism by which Vav3 controls leukemic cell proliferation is through a non-canonical nuclear function associated with the nucleation of PRC complex components and the control of PRC1.4 activity. The authors demonstrate that Vav3 becomes unexpectedly upregulated and activated in the nucleus of both human and murine lymphoblastic leukemia progenitors . . .
  

   

  

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