HIGHLIGHTS
- who: Shayin V. Gibson from the Maspin, and, Given their loss in IDC, the myoepithelial barrier has been long thought to act as a physical barrier, preventing carcinoma cells from invading into the stroma. However, emerging evidence suggests that myoepithelial cells can become altered to lose their tumour suppressive properties, and even enhance the proliferation and invasion of cancer cells13, . Serial analysis of myoepithelial gene expression revealed that chemokines , and , were overexpressed in DCIS, with subsequent functional assays confirming their ability to enhance proliferation and migration of epithelial cells13. DCIS-derived myoepithelial cells also exhibit reduced Laminin . . .
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