Impaired integrated stress response and mitochondrial integrity modulate genotoxic stress impact and lower the threshold for immune signalling

HIGHLIGHTS

  • who: Mihaela Temelie and collaborators from the Department of Life and Environmental Physics, Horia Hulubei National Institute for RandD in Physics and De Montfort University, The Gateway, Hawthorn Building, Leicester , BH, UK have published the Article: Impaired Integrated Stress Response and Mitochondrial Integrity Modulate Genotoxic Stress Impact and Lower the Threshold for Immune Signalling, in the Journal: (JOURNAL)
  • what: The authors show for the first time that CHOP and HtrA2 play a role in the transmission of intercellular signalling of genotoxic stress. The authors show that ISR loss of function as well as mitochondrial quality_control . . .

     

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