Clinical trajectories of individuals with severe mental illness continuing and discontinuing long-acting antipsychotics: a one-year mirror-image analysis from the star network depot study

HIGHLIGHTS

SUMMARY

Treatment adherence is a major issue for many severe mental disorders, as it has been associated with clinical relapse, rehospitalization, and functional deterioration1,2. Available evidence on LAIs is largely focused on people with schizophrenia-spectrum disorders, although in routine clinical practice these formulations are often prescribed off-label for other severe mental disorders, particularly bipolar and personality disorders, for which clinical evidence of efficacy and tolerability is relatively scant10-13. In these studies, however, those who discontinued the LAI during follow-up were either removed from the analysis or pooled with continuers16, which . . .

 



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