HIGHLIGHTS
- who: xin jin from the Division University of, Taipei, Taiwan have published the paper: WNK1 promotes water homeostasis by acting as a central osmolality sensor for arginine vasopressin release, in the Journal: (JOURNAL)
- what: This study demonstrated that an intracellular protein kinase WNK1 was involved. The authors show that WNK1 functions as a central osmolality sensor in_vivo that detects physiological ranges of hypertonicity to stimulate AVP release. The authors show that mice with neuronal-specific Wnk1 deletion have water homeostasis defects consistent with partial central DI. Using retrograde viral tracing the authors show that deletion . . .
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