HIGHLIGHTS
SUMMARY
Activated neutrophils release neutrophil extracellular traps (NETs)-a DNA-weblike structure embedded with neutrophil microbicidal/cytotoxic proteases, enzymes, and decondensed histones - to entrap and eliminate pathogens. The number (#) of DEspR + vs DEspR(-) was calculated by multiplying the %DEspR + x ANC obtained on the same day complete blood count (CBC)-differential, #DEspR + or DEspR + counts. In the analysis of a hypothetical treatment that eliminates DEspR + among patients with a SOFA score of 2 or more, elimination of DEspR + was associated with an indirect effect of a 1-point decrease in subsequent SOFA score, which for . . .
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