HIGHLIGHTS
- who: Nicolas Allu00e8gre from the CNRS have published the research: NANOG initiates epiblast fate through the coordination of pluripotency genes expression, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: Altogether, this analysis shows that in mouse embryos, ICM cells display two distinct cell heterogeneities. The work demonstrates that two distinct ICM cell states are successively present in the developing blastocyst, designated as primary heterogeneity or salt and pepper heterogeneity. The authors focused on single and double mutant embryos at stage 32-50C, because this is the time of appearance of Fgf4+ cells and of Epi . . .
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