Senescence rewires microenvironment sensing to facilitate antitumor immunity

HIGHLIGHTS

  • who: Hsuan-An Chen and colleagues from the (UNIVERSITY) have published the article: Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity, in the Journal: (JOURNAL) of 20/04/2023
  • what: Of note, the set of cell surface- enriched proteins identified in the model showed limited overlap with those identified in human fibroblasts undergoing oncogene-induced senescence , suggesting heterogeneity between cell types or senescence triggers. In the model , the difference between tumor senescent cell clearance and persistence was determined, at least in part, by the presence of environmental IFNu03b3 and the integrity of the type II . . .

     

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