Effectiveness of analgesic ear drops as add- on treatment to oral analgesics in children with acute otitis media: study protocol of the optima pragmatic randomised controlled trial

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• who: Joline L H de et al. from the which the control group receives usual care, is most suited for u2018real-u00ad world` cost-u00ad effectiveness analysisHowever, the lack of blinding in combination with the subjective, parent-u00ad reported outcomes might also lead to bias in the assessment of analgesic effects. To minimise this potential bias, the study physician will emphasise during the baseline visit that it is not known whether the drops have any effect in children with AOM. Furthermore, a recent meta-u00adepidemiological study found no evidence for a difference in estimated treatment effect between . . .
  

   

  

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