Mmupv1 e7’s interaction with ptpn14 delays epithelial differentiation and contributes to virus-induced skin disease

HIGHLIGHTS

  • who: James C. Romero-Masters and collaborators from the McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health have published the research: MmuPV1 E7u2019s interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease, in the Journal: (JOURNAL) of April/10,/2023
  • what: The authors investigated how the interaction of MmuPV1 E7 with the cellular tumor suppressor protein PTPN14 contributes to viral pathogenesis using a MmuPV1 E7 mutant defective for interacting with PTPN14 E7K81S. The study shows that an intact PTPN14 binding site is important for MmuPV1 . . .

     

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