HIGHLIGHTS
- who: Laetitia A. Hughes from the (UNIVERSITY) have published the Article: Copy number variation in tRNA isodecoder genes impairs mammalian development and balanced translation, in the Journal: (JOURNAL) of 29/03/2023
- what: The authors show that tRNA-Phe-1-1 is required for neuronal function and its loss is partially compensated by increased expression of other tRNAs but results in mistranslation. The authors show that the loss of tRNA-Phe-1-1-/- caused the most pronounced reduction in total tRNA-Phe levels in the liver and brain compared to control mice Nature Communications | 14 . . .
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