HIGHLIGHTS
SUMMARY
Cardiovascular disease is still the main cause of mortality worldwide, and coronary artery disease (CAD) is a major public health concern. While lifestyle changes, management of CAD risk factors, myocardial revascularization procedures, and medication can improve a patient`s prognosis, de novo native coronary lesions and in-stent restenosis (ISR) remain significant clinical concerns. In patients with a history of multiple myocardial revascularization interventions and ISR, it is difficult to differentiate de novo native coronary lesions from ISR. ISR is defined as a stent segment or its margins with a ≥50% stenosis of the . . .
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