Genetic deletion of phosphodiesterase 4d in the liver improves kidney damage in high-fat fed mice: liver-kidney crosstalk

HIGHLIGHTS

• who: Xiang Tao from the Animals and treatments Animal experiments were performed following the National Institutes of Health Guide for the Care and Use of Laboratory AnimalsAll animal studies were approved by the Animal Experimentation Ethics Committee of Huazhong University of Science and Technology. Liver-specific knockout of PDE D (PDE, LKO) was generated by breeding Albumin-Cre mice with PDE Dfl/fl mice (a gift from Dr. Yang K. Xiang, UC Davis, USA). Cre recombinase-negative littermate mice were used as controls (WT). Fiveweek-old male PDE, LKO mice and WT mice were fed a HFD . . .
  

   

  

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