The zinc-finger protein zcchc3 inhibits line-1 retrotransposition

HIGHLIGHTS

• who: Jiwei Ding and colleagues from the Yangzhou University, China have published the Article: The Zinc-Finger protein ZCCHC3 inhibits LINE-1 retrotransposition, in the Journal: (JOURNAL)
• what: The authors first investigate the role of ZCCHC3 in the IFN-I response of LINE-1.
• how: Together these data indicated that ZCCHC3 can restrict LINE1 retrotransposition. The result showed that ectopically expressed ZCCHC3 significantly reduced the copy number of the non-intron luciferase gene thus confirming the repression of LINE-1 by ZCCHC3 independently of luciferase reporter gene_expression ZCCHC3 decreases LINE-1 RNA level . . .
  

   

  

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