Crispr/cas9-mediated deletion of interleukin-30 suppresses igf1 and cxcl5 and boosts socs3 reducing prostate cancer growth and mortality

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SUMMARY

C, D Western blot analyses of IL30 protein expression in the cytosolic and plasma_membrane fractions of wild_type, NTgRNA-treated, IL30KO, EV and IL30 gene-transfected DU145 (C) and PC3 (D) cells. I Western blot analysis of IL30 protein expression in wild_type, EV- and IL30 gene-transfected TRAMP-C1 cells. J Mean volume of tumors developed in C57BL/6J mice, after s.c. implantation of wild_type, EV- or IL30-TRAMP-C1 cells. Tukey HSD test, p and amp;lt; 0.01 versus wild_type or EV-TRAMP-C1 cells. ANOVA, p and amp;lt; 0.001 . . .

 



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