A targetable coq-fsp1 axis drives ferroptosis- and radiation-resistance in keap1 inactive lung cancers

HIGHLIGHTS

• who: Pranavi Koppula from the The University of Texas MD Anderson Cancer Center, Houston, TX, USA have published the research work: A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 27/09/2021
• what: Together, the study proposes that KEAP1-NRF2 controls both the SLC7A11-GSH-GPX4 and CoQ-FSP1 arms for ferroptosis defense; consequently, if one arm is disabled, KEAP1 deficient cancer cells can still utilize the other arm to defend against ferroptosis. The authors showed that FSP1 is overexpressed . . .
  

   

  

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