Nanoparticle-mediated targeting of the fusion gene runx1/eto in t(8;21)-positive acute myeloid leukaemia

HIGHLIGHTS

• who: Hasan Issa from the (UNIVERSITY) have published the article: Nanoparticle-mediated targeting of the fusion gene RUNX1/ETO in t(8;21)-positive acute myeloid leukaemia, in the Journal: (JOURNAL) of 23/02/2023
• what: The authors show that targeting RUNX1/ETO by a chemically modified siRNA encapsulated into LNPs interferes with leukaemic propagation both in tissue_culture and in_vivo suggesting this approach as a therapeutic option for t(8;21) AML patients. This study provides insight in the mechanisms underlying these phenotypic changes. The authors show that LNP-mediated delivery of a fusion genespecific . . .
  

   

  

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