HIGHLIGHTS
- who: Yuxia Ma from the Department of Internal China have published the research work: Delivery of CXCL9/10/11 plasmid DNAs promotes the tumor-infiltration of T cells and synergizes with PD1 antibody for treating lung cancer, in the Journal: (JOURNAL)
- what: The major reason of PD1/PDL1 inhibitor resistance is the low rate of tumor T_cell infiltration (Bonaventura et_al 2019). The authors utilized the PBAE nanoparticles containing plasmids encoding CXCL9, CXCL10, and CXCL11 to deliver these plasmids to tumor cells to induce chemokine expression, and investigated the potential anti-tumor effects of these nanoparticles . . .
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