HIGHLIGHTS
- who: Shunsuke Kawasaki from the (UNIVERSITY) have published the Article: Programmable mammalian translational modulators by CRISPR-associated proteins, in the Journal: (JOURNAL) of 24/01/2023
- what: The authors report CARTRIDGE (Cas-Responsive Translational Regulation Integratable into Diverse Gene control) to repurpose Cas proteins as translational modulators in mammalian cells. The authors demonstrate that a set of Cas proteins efficiently and orthogonally repress or activate the translation of designed mRNAs that contain a Cas-binding RNA motif in the 5`-UTR. The authors show that various CRISPR-related technologies like anti-CRISPR and split-Cas9 . . .
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