Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions

HIGHLIGHTS

• who: Kitty Reemst from the Experimental design, breeding, and early-life stress model To determine the acute and long-term effects of ELS on microglia, we exposed seven different cohorts of mice to ELS or control (CTR) conditions from postnatal days (P), to , via the limited bedding and nesting model (see Supplementary Methods)We confirmed across the generated cohorts for this study the reduction in body weight gain between , and , in ELSexposed mice (Fig. S A) [38, ]. Male mice were used in all experiments. Cohort , was used for morphological characterization of microglia , hours after PBS or LPS . . .
  

   

  

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