Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma

HIGHLIGHTS

• who: Marta Larrayoz from the (UNIVERSITY) have published the research: Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma, in the Journal: (JOURNAL) of 16/03/2023
• what: In this scenario, the authors show that IgM-secreting MM constitutes a distinct BM disease of non-class-switched PCs derived from early B lymphocytes, which matches recent studies in patients with IgM MM27. Based on these experimental results, the authors propose that MM is driven by genetically heterogeneous lesions that converge in a common MYC oncogenic pathway, which imposes . . .
  

   

  

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