Exploiting volume electron microscopy to investigate structural plasticity and stability of the postsynaptic compartment of central synapses

HIGHLIGHTS

  • who: Greta Maiellano from the Raffaele University, Italy have published the paper: Exploiting volume electron microscopy to investigate structural plasticity and stability of the postsynaptic compartment of central synapses, in the Journal: (JOURNAL)

SUMMARY

    Indeed, alteration and/or disruption of neural circuits can have huge consequences on synapse structure and dynamics as demonstrated by their involvement in diverse pathological conditions such as motor and learning disabilities, altered mental status, cognitive impairment, neurodegenerative diseases (Chidambaram et_al, 2019; Borczyk et_al, 2021). In EM micrographs, these clusters of proteins are detectable as an electron-dense flattened . . .

     

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