HIGHLIGHTS
- who: Xiaoyang Wang from the (UNIVERSITY) have published the Article: Molecular basis for METTL9-mediated N1-histidine methylation, in the Journal: (JOURNAL)
SUMMARY
SAH interacts with METTL9M6 mainly via hydrogen_bonding interactions, with its adenosine ring sandwiched between Leu175 and Leu211 of METTL9M6. Specifically, the ribose O3` and O4` atoms of SAH are hydrogen_bonded to Glu174 of METTL9M6; the SAH amide is hydrogen_bonded to the main chain of Leu; and the carboxylate groups of SAH form polar interactions with the side chains of Asn210 and Tyr295 (Supplementary Fig S1d). The C2 and N3 atoms . . .
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