HIGHLIGHTS
SUMMARY
The authors investigated the prognostic significance of ZNF704 using data from TCGA database and performed preliminary functional experiments to validate its roles in_vivo and in_vitro and transcriptomic analysis to reveal its molecular mechanism. The Cancer Genome Atlas (TCGA) Correlation between ZNF704 expression and UM patients` survival was analyzed from There were 15 genes up-regulated in ZNF704 silenced UM cells and were negatively correlated with ZNF704 in human UM samples, including SORBS3 (Fig 7A and B). The authors demonstrated that ZNF704 expression promoted UM cell growth and migration and ZNF704 silencing induced cell cycle . . .
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