Trimming the genomic fat: minimising and re-functionalising genomes using synthetic biology

HIGHLIGHTS

• who: Xin Xu from the Synthesis of a Scerevisiae genome In parallel to the success of de novo synthesis of bacterial genomes, a global consortium led by Jef Boeke at New York University has been pursuing an ambitious project Sc2.0, aiming to build the first synthetic eukaryotic genome, that of S. cerevisiae. The aim of the project is not only to gain insights into yeast genomics, but also to create a simpler version of a yeast cell with comparable fitness to wild-type, which could be streamlined and refactored for different engineering purposes. The following changes . . .
  

   

  

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