Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the dna damage response

HIGHLIGHTS

• who: Pradeep Ramalingam from the (UNIVERSITY) have published the paper: Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the DNA Damage Response, in the Journal: (JOURNAL) of 17/08/2022
• what: The authors show that Netrin-1 plays an essential role in maintaining active DNA damage responses (DDR), and that aging-associated decline in niche-derived Netrin-1 results in DNA damage accumulation within the BM microenvironment. The authors show that Netrin-1 supplementation is sufficient to resolve DNA damage and restore regenerative potential of the aged BM niche and blood . . .
  

   

  

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