Potent dual magl/faah inhibitor aku-005 engages endocannabinoids to diminish meningeal nociception implicated in migraine pain

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SUMMARY

    Migraine is a common brain disorder that is characterized by a throbbing pain of generally unilateral nature, as well as other neurological symptoms that may vary between patients. The authors here aim to determine the functional role of endoCBs AEA and 2-AG, as well as MAGL and FAAH enzymes activity, in rat meninges high potassium-induced spiking activity. For testing MAGL/FAAH activity and measuring 2-AG and AEA levels, meninges from 6 rats were used, where "N" refers to the number of rat meninges. The degranulation of mast cells in meninges, which . . .

     

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