Parahydrogen-induced polarization allows 2000-fold signal enhancement in biologically active derivatives of the peptide-based drug octreotide

HIGHLIGHTS

• who: Jonas Lins from the Universitu00e4t have published the Article: Parahydrogen-induced polarization allows 2000-fold signal enhancement in biologically active derivatives of the peptide-based drug octreotide, in the Journal: Scientific Reports Scientific Reports of 14/04/2023

SUMMARY

All variants, including the original octreotide (1, Fig 2), were synthesized manually by solid-phase peptide synthesis (SPPS) on a 2-chlorotritylchloride resin using the Fmoc s­ trategy50. To better investigate the hydrogenation products of 2-A1 and 2-A3, l-allyl tyrosine (B) was introduced by SPPS to obtain the variants OctF1AllAc . . .

 



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