Lentivector cryptic splicing mediates increase in cd34+ clones expressing truncated hmga2 in human x-linked severe combined immunodeficiency

HIGHLIGHTS

• who: Suk See Ravin from the IncUniversity have published the research work: Lentivector cryptic splicing mediates increase in CD34+ clones expressing truncated HMGA2 in human X-linked severe combined immunodeficiency, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The patients at entry into the study had donor engraftment in only the T lymphocyte lineage, required supplemental IgG, and had increasing medical problems including in most cases chronic norovirus infection. The authors show transcriptional profiling of peripheral blood immune cells and single-cell colony analysis of CD34+ HSCs and 2 inducible pluripotent stem_cells (iPSCs) reveal vector . . .
  

   

  

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