HIGHLIGHTS
- who: Valentina Taglietti from the Systemu201d Team, Cru00e9teil, France have published the research: Duchenne muscular dystrophy trajectory in R-DMDdel52 preclinical rat model identifies COMP as biomarker of fibrosis, in the Journal: (JOURNAL)
- what: The authors show that R-DMDdel52 animals recapitulated human DMD pathophysiological more faithfully than the mdx mouse model. The authors report that R-DMDdel52 rats displayed progressive and severe skeletal muscle loss associated with fibrotic deposition fat infiltration and fibre type switch. The authors show that DMD fibroadiu2011 pogenic progenitors produced elevated levels of cartilage oligomeric matrix protein a glycoprotein responsible . . .
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