HIGHLIGHTS
SUMMARY
Molecules Targeting Kidney ClC-K Human ClC-Ka and ClC-Kb are double-barreled chloride channels belonging to the family of ClC proteins. ClC-Ka and ClC-Kb are homologous epithelial chloride channels mainly expressed in the kidney and inner ear, where they play a pivotal role in chloride homeostasis. Over the last few years, pharmacological research has been committed to developing drugs acting as modulators of ClC-K channels with the aim of providing better therapeutic treatment for patients affected by ClC-K-associated disorders. The identification of barttin as an essential ClC . . .
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