Yy1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of fgf2

HIGHLIGHTS

• who: Xiaotang Wang from the of, China have published the research: YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2, in the Journal: (JOURNAL)
• what: The authors demonstrate that hypoxia-induced hyperlactylation in microglia plays pivotal roles in retinal neovascularization.
• how: The results showed that p300 HDAC6 and SIRT1 levels were significantly upregulated and Tip60 levels were slightly upregulated in HMC3 microglia under hypoxia (Fig 6a and Additional file 1 Fig S4a). The data showed that lactylation at lysine 183 of the nonhistone protein YY1 leads to an increase . . .
  

   

  

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