-synuclein preformed fibrils bind to -neurexins and impair -neurexin-mediated presynaptic organization

HIGHLIGHTS

  • who: Benjamin Feller et al. from the Montreal, QC H W , Canada Neurological Institute-Hospital, McGill University, Montreal, QC H A , Canada have published the research work: -Synuclein Preformed Fibrils Bind to -Neurexins and Impair -Neurexin-Mediated Presynaptic Organization, in the Journal: Cells 2023, 12, 1083. of /2023/
  • how: The following deletion constructs and point mutations for extracellular hemagglutinin (HA)-tagged NRX1u03b2S4(-) (NP_001333889.1) (HA-NRX1u03b2S4(-)) were made by inverse PCR with the vector expressing HA-NRX1u03b2S4(-) under the CMV promoter as a PCR template followed by DpnI digestion u2206LNS (amino_acids (aa) 107-236 deleted . . .

     

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