Evolution-informed strategies for combating drug resistance in cancer

HIGHLIGHTS

  • who: Kristi Lin-Rahardja and collaborators from the Systems Biology and Bioinformatics, Case Western Reserve University, Cleveland, OH, USA have published the article: Evolution-Informed Strategies for Combating Drug Resistance in Cancer, in the Journal: (JOURNAL)
  • what: Some of this work has been summarized in other excellent reviews . As an example, the authors propose the pipeline illustrated in Figure 3.
  • how: This experimental method can be used to examine the evolutionary dynamics of evolving cells by inserting heritable barcode tags in individual cells within a starting population and characterizing phenotypic changes in the . . .

     

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