HIGHLIGHTS
SUMMARY
To date, numerous studies have demonstrated effects of e-stim on metabolism, force production, and fiber phenotype (Nikolić et_al, 2012; Khodabukus et_al, 2015; Khodabukus et_al, 2019; Chen et_al, 2021) in 2D and 3D muscle culture models. Emerging research in muscle-derived extracellular vesicles (EVs), which carry proteins, lipids, mRNAs and microRNAs (miRs), has provided further insight into mechanisms of crosstalk between muscle and other tissues (Guescini et_al, 2010; Forterre et_al, 2014; Yoon et_al, 2014; Rome et_al, 2019). All cells export various cellular cargo, including miRs, through EVs-which are synthesized via budding of the . . .
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