Notch signaling regulates the chondrogenic potential of both articular chondrocytes and their progenitors during expansion

HIGHLIGHTS

  • who: Karthik R from the InstitutMedical University Moscow, Russia have published the paper: Notch signaling regulates the chondrogenic potential of both articular chondrocytes and their progenitors during expansion, in the Journal: (JOURNAL)
  • what: The authors attempted to optimize conditions for the expansion of artSPCs without compromising their chondrogenic potential.
  • how: For further characterization of the obtained pellets the authors employed Sox9 to mark chondrocytes and chondroprogenitors Collagen II to mark mature chondrocytes Collagen I which marks osteoblasts as well as fibrocartilage and Runx2 a master transcription factor for osteolineage differentiation but also marks . . .

     

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