Heterotypic signaling of cancer-associated fibroblasts in shaping the cancer cell drug resistance

HIGHLIGHTS

  • who: Ramesh Butti et al. from the Department of Internal Medicine, Division of Hematology and Oncology, University of Texas Southwestern Medical Center, Dallas, TX, USA have published the paper: Heterotypic signaling of cancer-associated fibroblasts in shaping the cancer cell drug resistance, in the Journal: (JOURNAL)
  • what: The studies focused on targeting CAFs for the management of cancer have challenged this dogma.
  • future: AND FUTURE DIRECTIONS Stromal fibroblasts constitute a major component of tumor microenvironment.

SUMMARY

    Tumor microenvironments consist of various kinds of non-cancerous cells such as fibroblasts . . .

     

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