M6a modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis

HIGHLIGHTS

  • who: Xiaohan Jiang from the University of the Witwatersrand, South Africa have published the research: m6A modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis, in the Journal: (JOURNAL)
  • future: Future research can better understand and explain the different roles of METTL3 and METTL14 in CRC by delving into the interaction between m6A and tumorigenesis.

SUMMARY

    Functionally, METTL3 knockdown drastically inhibited CRC stemness in_vitro and suppressed CRC growth and metastasis in cell-based and PDX-based subcutaneous tumor models. Ma et_al confirmed the oncogenic role . . .

     

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