C-di-amp signaling plays important role in determining antibiotic tolerance phenotypes of mycobacterium smegmatis

HIGHLIGHTS

• who: Aditya Kumar Pal from the (UNIVERSITY) have published the Article: c-di-AMP signaling plays important role in determining antibiotic tolerance phenotypes of Mycobacterium smegmatis, in the Journal: Scientific Reports Scientific Reports
• how: At this point the authors hypothesized that the category I mutants which showed a lesser degree of MIC modulation and no mutation in the QRDR hotspot region of the gyrA gene could harbor mutations leading to high efflux activity.

SUMMARY

The gyrA ­94th amino_acid mutation seemed to have a moderate fitness cost in WT and ΔdisA category . . .

 



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