Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer

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SUMMARY

Received: 5 April 2022 Martin Boström and amp; Erik Larsson Check for updates Accepted: 4 November 2022 Cancer gene discovery is reliant on distinguishing driver mutations from a multitude of passenger mutations in tumour genomes. The authors take advantage of the fact that non-cancer genes, containing only passenger mutations under neutral selection, exhibit a likelihood of mutagenesis in a given tumour determined by the tumour`s mutational signature and burden. This relationship can be disrupted by positive selection, leading to a difference in the distribution of mutated cases across a cohort for . . .

 



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