Hox epimutations driven by maternal smchd1/lrif1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring

HIGHLIGHTS

• who: Shifeng Xue from the National University, INSERM, Marseille Medical Genetics, Marseille, France have published the Article: HOX epimutations driven by maternal SMCHD1/LRIF1 haploinsufficiency trigger homeotic transformations in genetically wildtype offspring, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 15/07/2021
• what: The authors show that loss of smchd1 in zebrafish causes derepression of a large number of hox genes resulting in aberrant skeletal patterning. This intergenerational inheritance documented in zebrafish which the authors propose is driven by Hox epi-mutations, may also be at play in higher vertebrate species including mammals. The . . .
  

   

  

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