Hiv-1 rev-rre functional activity in primary isolates is highly dependent on minimal context-dependent changes in rev

HIGHLIGHTS

  • who: Godfrey Dzhivhuho from the University of have published the paper: HIV-1 Rev-RRE functional activity in primary isolates is highly dependent on minimal context-dependent changes in Rev, in the Journal: Scientific Reports Scientific Reports
  • how: This difference in activity persisted when the Revs were tested in combination with RREs from the 8-G and 9-G primary isolates (p and amplt 0.001 for both comparisons). The authors hypothesized that this difference could account for the decreased activity of the 9-G.I19V mutant relative to native 9-G as well as . . .

     

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