1,3,8-triazaspiro[4.5]decane derivatives inhibit permeability transition pores through a fo-atp synthase c subunit glu119-independent mechanism that prevents oligomycin a-related side effects

HIGHLIGHTS

  • who: Gaia Pedriali and colleagues from the Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy have published the research work: 1,3,8-Triazaspiro[4.5]decane Derivatives Inhibit Permeability Transition Pores through a FO-ATP Synthase c Subunit Glu119-Independent Mechanism That Prevents Oligomycin A-Related Side Effects, in the Journal: (JOURNAL)
  • what: The aims of this study are to (i) identify for the first time the topologically equivalent residues in the human Csub sequence; (ii) provide their in vitro validation in A-mediated PTP inhibition and_(iii) understand their relevance . . .

     

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