Prediction of evolutionary constraint by genomic annotations improves functional prioritization of genomic variants in maize

HIGHLIGHTS

• who: Guillaume P. Ramstein from the Center for Quantitative University, Denmark have published the research work: Prediction of evolutionary constraint by genomic annotations improves functional prioritization of genomic variants in maize, in the Journal: (JOURNAL)
• what: The authors aimed at capturing the genomic basis for fitness effects in coding regions in maize, by predicting PNC at nonsynonymous mutations from genomic annotations. The model showed little sensitivity to hyperparameters, as exemplified by the low range of classification accuracy in chromosome 8 (0.6%) across hyperparameters (Additional file 1: Fig S2).
• future: The results will . . .
  

   

  

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