HIGHLIGHTS
SUMMARY
In the tumor stroma, cancer-associated fibroblasts (CAF`s) remodel tumor ECM and reorient collagen fibers perpendicularly to the tumor boundary, facilitating breast cancer cell invasion into the neighbouring tissues. Indeed, the lack of studies on the mechanics of decellularized tumors has prevented the correlative assessment of tumor ECM stiffness with other tumor features, such as size, deposition of specific ECM components or the presence of necrosis. The relative locations of the ECM-rich regions within the tumor also indicated a connection between ECM deposition and tumor necrosis, as they largely overlapped. Upon closer . . .
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