Cdgap maintains podocyte function and modulates focal adhesions in a src kinase-dependent manner

HIGHLIGHTS

• who: Jun Matsuda from the DivisionMcGill University have published the research: CdGAP maintains podocyte function and modulates focal adhesions in a Src kinase-dependent manner, in the Journal: Scientific Reports Scientific Reports
• what: In the current study, CdGAP KD podocytes showed increased basal activities of Rac1 and Cdc42, indicating that CdGAP suppresses both Rac1 and Cdc42 activities under basal conditions. This study demonstrated that u03b2-PIX interacts not only with Cdc42 but also with Rac1, and furthermore with CdGAP in podocytes.

SUMMARY

Loss of CdGAP enhances Rac1 and Cdc42 activities and . . .

 



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