New snca mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy

HIGHLIGHTS

• who: Yang Yang from the Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK have published the Article: New SNCA mutation and structures of u03b1-synuclein filaments from juvenile-onset synucleinopathy, in the Journal: (JOURNAL)
• what: The authors report a duplication of 21 nucleotides in one allele of SNCA in a case of JOS, which inserts the sequence MAAAEKT after residue 22 of u03b1-synuclein.

SUMMARY

The authors now report the cryo-EM structures of α-synuclein filaments from the frontal cortex of this case. Both wild-type and mutant proteins are . . .

 



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